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Eur Neuropsychopharmacol · Dec 2005
Randomized Controlled TrialDeramciclane in the treatment of generalized anxiety disorder: a placebo-controlled, double-blind, dose-finding study.
- Hannu Naukkarinen, Roope Raassina, Jukka Penttinen, Antti Ahokas, Riitta Jokinen, Hannu Koponen, Ulla Lepola, Harri Kanerva, Leena Lehtonen, Tiina Pohjalainen, Auli Partanen, Outi Mäki-Ikola, Juha Rouru, and Deramciclane Dose-Finding Study Group.
- Department of Psychiatry, University of Helsinki, Box 320 (Lapinlahdentie), FIN-00180, HUCH, Helsinki, Finland. hannu.naukkarinen@hus.fi
- Eur Neuropsychopharmacol. 2005 Dec 1; 15 (6): 617-23.
AbstractDeramciclane, a camphor derivative, is a novel anxiolytic agent with a unique mechanism of action. It acts as a potent and specific antagonist at serotonin 5-HT2A/2C receptors, and exhibits anxiolytic efficacy in animal models. The aim of this double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy, safety, and tolerability of a range of doses of deramciclane in patients with generalized anxiety disorder (GAD). Adult patients with a diagnosis of GAD (DSM-IV) and a Hamilton Anxiety Rating Scale (HAM-A) total score >or=18; a score >or=2 for the HAM-A items 'Anxious Mood' and 'Tension'; a score >or=4 on the Clinical Global Impression of Severity of Illness (CGI-S) Scale; and a score
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