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Clin. Microbiol. Infect. · May 2013
Case ReportsIntrapatient emergence of OXA-247: a novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae.
- S Gomez, F Pasteran, D Faccone, M Bettiol, O Veliz, D De Belder, M Rapoport, B Gatti, A Petroni, and A Corso.
- Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS-Dr Carlos G. Malbran, Buenos Aires, Argentina. sgomez@anlis.gov.ar
- Clin. Microbiol. Infect. 2013 May 1; 19 (5): E233-5.
AbstractTwo genetically related Klebsiella pneumoniae strains carrying OXA-type carbapenemases were isolated from a single patient 1 month apart. Kpn163 harboured OXA-163 and Kpn247 a new variant named OXA-247 that showed susceptibility to carbapenems and expanded-spectrum cephalosporins similar to OXA-48. Our epidemiological, biochemical and molecular results suggest the intrapatient emergence of blaOXA -247 from blaOXA -163.© 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.
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