• Dorothy K Hatsukami, Michael Kotlyar, Louise A Hertsgaard, Yan Zhang, Steven G Carmella, Joni A Jensen, Sharon S Allen, Peter G Shields, Sharon E Murphy, Irina Stepanov, and Stephen S Hecht.
• University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA. hatsu001@umn.edu
• Addiction. 2010 Feb 1; 105 (2): 343-55.

AimsTo examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence.DesignRandomized, parallel arm, semi-blinded study. Setting University of Minnesota Tobacco Use Research Center.InterventionsSix weeks of: (i) 0.05 mg nicotine yield cigarettes; (ii) 0.3 mg nicotine yield cigarettes; or (iii) 4 mg nicotine lozenge; 6 weeks of follow-up. Measurements Compensatory smoking behavior, biomarkers of exposure, tobacco dependence, tobacco withdrawal and abstinence rate.FindingsUnlike the 0.3 mg cigarettes, 0.05 mg cigarettes were not associated with compensatory smoking behaviors. Furthermore, the 0.05 mg cigarettes and nicotine lozenge were associated with reduced carcinogen exposure, nicotine dependence and product withdrawal scores. The 0.05 mg cigarette was associated with greater relief of withdrawal from usual brand cigarettes than the nicotine lozenge. The 0.05 mg cigarette led to a significantly higher rate of cessation than the 0.3 mg cigarette and a similar rate as nicotine lozenge.ConclusionThe 0.05 mg nicotine yield cigarettes may be a tobacco product that can facilitate cessation; however, future research is clearly needed to support these preliminary findings.

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