• Enferm. Infecc. Microbiol. Clin. · Mar 2008

    [Inflammatory response in elderly patients with bacteremia].

    • Luis Martí, Carlos Cervera, Xavier Filella, José Luis Marín, Manel Almela, José M Gatell, and Asunción Moreno.
    • Servicio de Infecciones, Hospital Clínico-IDIBAPS, Universidad de Barcelona, Barcelona, Spain.
    • Enferm. Infecc. Microbiol. Clin. 2008 Mar 1; 26 (3): 146-9.

    ObjectiveTo evaluate inflammatory markers (C reactive protein [CRP], interleukina-1beta [IL-1beta], IL-6 and tumoral necrosis factor [TNF-alpha]) as predictors of bloodstream infection in elderly patients with systemic inflammatory response syndrome (SIRS).MethodsBlood cultures and markers were performed at admission and on day 4.ResultsEighty-two patients were included, 34% with positive blood cultures. TNF-alpha and IL-6 values at admission were higher in patients with positive blood cultures (84.5 vs. 28.5 pg/mL [P = .001] and 192.5 vs. 113, [P = .017], respectively). TNF-alpha values on day 4 were higher in patients with positive cultures (50.5 vs. 30; P = .017).ConclusionsHigh TNF-alpha and IL-6 values at admission, and TNF-alpha values on day 4 correlated with bloodstream infection.

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