• Int J Gynaecol Obstet · Oct 2012

    Misoprostol for prevention and treatment of postpartum hemorrhage: what do we know? What is next?

    • Sheila Raghavan, Dina Abbas, and Beverly Winikoff.
    • Gynuity Health Projects, New York, NY 10010, USA. dabbas@gynuity.org
    • Int J Gynaecol Obstet. 2012 Oct 1; 119 Suppl 1: S35-8.

    AbstractMisoprostol is an effective and safe uterotonic for the prevention and treatment of postpartum hemorrhage (PPH). A 600-μg oral dose of misoprostol has been shown to prevent PPH in community-based randomized controlled trials. An 800-μg sublingual dose of misoprostol appears to be a good first-line treatment for controlling PPH. Adverse effects after use of misoprostol for PPH prevention or treatment may include shivering and fever. These effects are transient, resolve on their own, and are not life threatening. Misoprostol can play an important role in settings with limited access to oxytocin, and where there is no other option for PPH care.Copyright © 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

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