• Nikunjkumar Patel and George P Bayliss.
• Division of Kidney Diseases and Hypertension, Rhode Island and the Miriam Hospitals, Providence, RI, USA; Alpert Medical School, Brown University, Providence, RI, USA.
• Adv. Drug Deliv. Rev. 2015 Aug 1; 90: 3-11.

AbstractThe modern use of extracorporeal therapies to treat poisoning and drug overdoses dates back to the early 20th century and has evolved along with their use as treatment for acute kidney injury or as maintenance therapy in advanced kidney disease. As our understanding of drug pharmacokinetics and membrane materials has increased, the technologies of extracorporeal therapy and their applications have become more sophisticated. Despite that, there is little robust evidence to guide clinicians on the optimal use of extracorporeal therapy in treating poisoning beyond case reports and series. New efforts are underway to remedy that: the Extracorporeal Treatments in Poisoning Workgroup (EXTRIP) is an international effort on the part of nephrologists, pharmacists and toxicologists to review the available data and formulate evidence-based guidelines on how to use extracorporeal techniques to treat poisoning and improve patient outcomes. Meanwhile, new techniques and membranes are under development. This review will summarize those key scientific and technologic developments, the efforts to optimize their use and new directions in research.Copyright © 2015 Elsevier B.V. All rights reserved.

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