• Laxmaiah Manchikanti, Frank J E Falco, Ramsin M Benyamin, David L Caraway, Timothy R Deer, Vijay Singh, Haroon Hameed, and Joshua A Hirsch.
• Pain Management Center of Paducah, Paducah, KY, USA.
• Pain Physician. 2013 Apr 1;16(2 Suppl):SE25-54.

BackgroundLumbar disc prolapse, protrusion, and extrusion account for less than 5% of all low back problems, but are the most common causes of nerve root pain and surgical interventions. The primary rationale for any form of surgery for disc prolapse is to relieve nerve root irritation or compression due to herniated disc material. The primary modality of treatment continues to be either open or microdiscectomy, although several alternative techniques are also utilized, including nucleoplasty, automated percutaneous discectomy and laser discectomy. There is a paucity of evidence for all decompression techniques, specifically alternative techniques including nucleoplasty.Study DesignA systematic review of the literature of mechanical lumbar disc decompression with nucleoplasty.ObjectiveTo determine the effectiveness and update the effectiveness of mechanical lumbar disc decompression with nucleoplasty.MethodsThe available literature on mechanical lumbar disc decompression with nucleoplasty was reviewed. The quality assessment and clinical relevance criteria utilized were the Cochrane Musculoskeletal Review Group criteria as utilized for interventional techniques for randomized trials and the criteria developed by the Newcastle-Ottawa Scale criteria for observational studies.The level of evidence was classified as good, fair, and limited or poor based on the quality of evidence developed by the U.S. Preventive Services Task Force (USPSTF) . Data sources included relevant literature identified through searches of PubMed and EMBASE from 1966 to September 2012, and manual searches of the bibliographies of known primary and review articles.Outcome MeasuresPain relief and functional improvement were the primary outcome measures. Other outcome measures were improvement of psychological status, reduction in opioid intake, and return to work. Short-term effectiveness was defined as one year or less, whereas long-term effectiveness was defined as greater than one year.ResultsFor this systematic review, 37 studies were considered for inclusion. Of these, there was one randomized trial and 14 observational studies meeting inclusion criteria for methodological quality assessment.Based on USPSTF criteria, the level of evidence for nucleoplasty is limited to fair in managing radicular pain due to contained disc herniation.LimitationsA paucity of literature with randomized trials.ConclusionsThis systematic review illustrates limited to fair evidence for nucleoplasty in managing radicular pain due to contained disc herniation.

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