• J. Trop. Pediatr. · Apr 2013

    Randomized Controlled Trial

    Bubble CPAP versus ventilator CPAP in preterm neonates with early onset respiratory distress--a randomized controlled trial.

    • Amit Tagare, Sandeep Kadam, Umesh Vaidya, Anand Pandit, and Sanjay Patole.
    • Division of Neonatology, Department of Pediatrics, KEM Hospital, Pune 411011, India.
    • J. Trop. Pediatr. 2013 Apr 1; 59 (2): 113-9.

    UnlabelledBubble continuous positive airway pressure (BCPAP) is a low cost nasal CPAP delivery system with potential benefits to developing nations.ObjectiveTo compare the efficacy and safety of BCPAP with ventilator-derived CPAP (VCPAP) in preterm neonates with respiratory distress.MethodsIn a randomized controlled trial, preterm neonates with Silverman-Anderson score ≥ 4 and oxygen requirement >30% within first 6 h of life were randomly allocated to BCPAP or VCPAP. Proportion of neonates with success or failure was compared.ResultsIn all, 47 of 57 (82.5%) neonates from BCPAP group and 36 of 57 (63.2%) neonates from the VCPAP group completed CPAP successfully (p = 0.03). Neonates who failed CPAP had higher Silverman-Anderson score (p < 0.01), lower arterial to alveolar oxygenation ratio (p < 0.05) and needed surfactant more frequently (p < 0.01).ConclusionBCPAP has higher success rate than VCPAP for managing preterm neonates with early onset respiratory distress, with comparable safety.

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