• Michiko Ohsuda, Mitsutaka Edanaga, Mitsuko Mimura, Yoshito Nakayama, Akinori Kirita, Shinji Koro, Kazuo Yamaya, Masato Kurihara, and Michiaki Yamakage.
• Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060-8543.
• Masui. 2012 Feb 1; 61 (2): 159-63.

BackgroundThe purpose of this study was to evaluate effects of landiolol hydrochloride, which is an ultra-short-acting beta-1 selective blocker, for intraoperative tachycardia and to establish practical methods of administration of the drug.MethodsWe retrospectively examined by multicenter questionnaires the effects and practical methods of administration of landiolol for 100 patients who showed tachycardia needing treatment during anesthesia. The techniques for anesthesia and administration of landiolol were entrusted to each anesthesiologist.ResultsOne case was excluded because the dose of landiolol hydrochloride was uncertain. Fifty-nine patients received an intravenous bolus injection of landiolol, and continuous injection was performed in 34 patients. Six patients had both bolus and continuous injections. In the 99 patients, heart rate was significantly reduced to desired levels. The time required to reduce heart rate by more than 10% after injection was shorter in the bolus group than in the continuous group. Bolus injection, however, did not reduce blood pressure. Although low-dose continuous administration significantly reduced blood pressure, treatment for increasing blood pressure was not needed in any of the patients.ConclusionsInformation obtained by the questionnaire suggests that bolus injection and/or low-dose continuous administration of landiolol, which are not described in the drug information documents, are effective and safe for treatment of tachycardia during anesthesia.

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