• Akhila Mallipedhi, Sarah L Prior, Jonathan D Barry, Scott Caplin, John N Baxter, and Jeffrey W Stephens.
• Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea, United Kingdom; Department of Diabetes & Endocrinology, Morriston Hospital ABM University Health Board, Swansea, United Kingdom. Electronic address: mallipedhi@doctors.org.uk.
• Surg Obes Relat Dis. 2014 Nov 1; 10 (6): 1123-8.

BackgroundBariatric surgery is an effective treatment for morbid obesity. Obesity and type 2 diabetes are associated with chronic inflammation. There is lack of data examining the effects of sleeve gastrectomy (SG) on inflammatory biomarkers. Our aim was to study the effects of SG on specific cytokines associated with obesity including interleukin-6 (IL-6), interleukin-10 (IL-10), leptin, adiponectin, and C-reactive protein (CRP) preoperatively, 1 and 6 months after surgery.MethodsA nonrandomized prospective study comprising of 22 participants with impaired glucose homeostasis and type 2 diabetes undergoing SG (body mass index 50.1 kg/m(2), glycated hemoglobin [HbA1c] 53 mmol/mol). Serial measurements of IL-6, IL-10, leptin, adiponectin, and CRP were performed during oral glucose tolerance testing preoperatively, 1 and 6 months postoperatively.ResultsWe observed significant improvements at 1 and 6 months in leptin (P≤.001) and CRP (P = .003) after SG. We also observed a significant reduction in IL-6 at 6 months (P = .001). No statistically significant differences were observed for adiponectin and IL-10.ConclusionThis study is the first to examine the detailed changes in the inflammatory cytokines after SG. Our study shows significant improvements in the inflammatory biomarkers after SG in patients with impaired glucose homeostasis and type 2 diabetes.Copyright © 2014 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

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