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Neuroscience research · Mar 2012
A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord: the effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats.
- Kei Morizane, Tadanori Ogata, Tadao Morino, Hideki Horiuchi, Gotaro Yamaoka, Masayuki Hino, and Hiromasa Miura.
- Spine Center, Ehime University Hospital, Tohon-city, Ehime 791-0295, Japan.
- Neurosci. Res. 2012 Mar 1; 72 (3): 279-82.
AbstractWe developed a novel thermoelectric cooling device using Peltier modules for the treatment of spinal cord injury in rats. The extracorporeal electrically cooling component was attached to the aluminum arched plate which was placed on the surface of the spinal cord after the contusion injury in the 11th thoracic spinal cord. During the hypothermic treatment, rats were awake and could move in the cage. Hind limb motor function, evaluated using a BBB scale, in the hypothermic animals (33°C for 48 h) was significantly higher than that in the normothermic animals from 2 weeks to 8 weeks after the injury.Copyright © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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