• Behav. Brain Res. · Aug 2007

    The effects of willed movement therapy on AMPA receptor properties for adult rat following focal cerebral ischemia.

    • Qingping Tang, Qidong Yang, Zhongyang Hu, Baoqiong Liu, Jianzhong Shuai, Gaiqing Wang, Zunjing Liu, Jian Xia, and Xiangmin Shen.
    • Department of Neurology, Xiang Ya Hospital, Central South University, Changsha 410008, Hunan, China. tqingpingjt@yahoo.com <tqingpingjt@yahoo.com>
    • Behav. Brain Res. 2007 Aug 6; 181 (2): 254-61.

    Background And PurposeAlthough we demonstrated willed movement (WM) therapy can facilitate the patients actively participating in the physical activities by cognitive and perceptual stimulation in our previous study, the molecular mechanisms of the willed movement on the patients remains unclear. We initially established the model of WM intervention for rats and identified possible effects of willed movement on motor recovery and on expression of Kainate/alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in ischemia core (IC) and ischemia penumbra (IP) regions of rats after cerebral ischemia reperfusion.MethodsSeventy-two adult male Sprague Dawley rats after successful 120-min period of occlusion of the left middle cerebral artery were selected and randomly divided into three groups: middle cerebral artery occlusion (MCAO), WM and environmental modification (EM). Neurological and neurobehavioral assessments were performed and the rats were killed at various recirculation times after MCAO. Reverse transcription-PCR were used to detect mRNA of GluR1-GluR4 subunit of AMPA receptors in the areas of IC and IP in all adult rats.ResultsRats following WM intervention showed significantly better acquisition of climbing (every time point tested), forelimb mobility and neurological functions at subacute stage of MCAO. No difference was found in the expression levels of GluR1-GluR4 mRNA among three groups in IC region. However, GluR1 and GluR4 mRNA of rats in group WM were significantly upregulated as compared with rats in group MCAO and group EM in IP region at subacute stage.ConclusionsEarly willed movement treatment can increase the expression level of AMPA receptor subunits and thus might increase synaptic transmission and enhance brain plasticity after focal brain ischemia at the subacute stage.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…