• Medical hypotheses · Dec 2011

    Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function.

    • Hong-Bing Xiang, Cheng Liu, Qing-Qing Guo, Rong-Chun Li, and Da-Wei Ye.
    • Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
    • Med. Hypotheses. 2011 Dec 1; 77 (6): 1135-8.

    AbstractDeep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) had usually been reported to improve the symptoms of advanced Parkinson's disease. Previous studies showed that neurons in the PPTg involved in the control of the sympathetic outflow to the kidneys. Our recent studies using transneuronal labeling pseudorabies virus (PRV)-614 supported the sympathetic nature of the caudal PPTg. We propose a hypothesis that deep brain stimulation of the PPTg may influence renal function by serotonergic and catecholaminergic pathways. Because PRV-614/tryptophan hydroxylase and PRV-614/tyrosine hydroxylase double-labeled neurons in the compact parts of PPTg (cpPPTg) were not detected, deep brain stimulation of the cpPPTg might not influence renal function.Copyright © 2011 Elsevier Ltd. All rights reserved.

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