• Ji Zhang, Jia-hua Leng, Hong-gang Qian, Hui Qiu, Jian-hui Wu, Bo-nan Liu, Cheng-peng Li, and Chun-yi Hao.
• Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Hepato-Pancreatic Biliary Surgery, Beijing Cancer Hospital, Peking University Cancer Hospital & Institute, Beijing, China.
• Dis. Colon Rectum. 2013 Jul 1; 56 (7): 874-80.

BackgroundCarcinoma of the right colon invading the pancreas or duodenum is rare. Evidence of the indication, operative morbidity, and survival of en bloc pancreaticoduodenectomy and right colectomy for right colon cancer invading adjacent organs is limited.Objective: The goal of this study was to investigate the feasibility, safety, indication, and long-term results of en bloc pancreaticoduodenectomy and right colectomy in the treatment of locally advanced right-sided colon cancer.Design: This was a retrospective analysis of all inpatients undergoing en bloc pancreaticoduodenectomy and right colectomy. Detailed data of these patients were assessed by a thorough review of medical charts.SettingsThe study was conducted using a hospital database.PatientsFourteen patients who underwent en bloc pancreaticoduodenectomy and right colectomy from January 1989 through December 2011 were included in the study.Main Outcome MeasuresIn-hospital complications, mortality, and survival were the primary outcomes measured.ResultsMajor postoperative complications included delayed gastric empting (n = 7), class B pancreatic fistula (n = 3), and bile leakage (n = 1). Postoperative death occurred in 2 patients. The median hospital stay was 22.5 days (range, 17.0-57.0 days). Inflammatory adhesion was confirmed by pathologic examination in only 1 patient. Eight patients (57%) did not have lymph node metastasis. The median follow-up time was 21 months (range, 4-276 months). Ten patients were alive at the time of their last scheduled follow-up. The overall survival rates were 72% at 1 year and 60% at 2 years. No patient was lost to follow-up. Three patients developed tumor recurrence. The outcomes are no worse than those of the stage-matched patients without adjacent organ involvement and are much better than those of the stage-matched patients who underwent bypass surgery and chemotherapy.LimitationsThe number of patients in current studies is limited.ConclusionsEn bloc pancreaticoduodenectomy and right colectomy can be performed safely with an acceptable morbidity and mortality rate in selected patients with locally advanced right-side colon cancer. The long-term results are promising.

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