• Brian K Ahmedani, Edward L Peterson, Karen E Wells, David E Lanfear, and L Keoki Williams.
• Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI; Department of Internal Medicine, Henry Ford Health System, Detroit, MI.
• Pain Physician. 2014 May 1; 17 (3): 205-16.

BackgroundRising prescription opioid use and abuse have prompted widespread concern. However, to date there have been few rigorous investigations into the policies and events which may have contributed to these trends.ObjectiveThis study investigates trends in opioid use and related adverse events among individuals with non-cancer pain before and after implementation of major national policies.Study DesignThe study used a longitudinal prospective study design. The analysis was limited to adults (age = 18 years) without a recorded cancer diagnosis. Pharmacy claims were used to assess rates of prescription opioid use, the strength of opioids dispensed, the proportion using opioids chronically, and related adverse events. Time trend analysis was used to identify changes in these rates over time. The study was Institutional Review Board approved.SettingStudy patients were members of a large, health maintenance organization in southeast Michigan, with longitudinal records of prescription opioid use.ResultsThe analysis comprised 523,623 individuals and 1,066,700 opioid pharmacy fills from January 1, 1997, to December 31, 2011. Contemporaneous with the implementation of health organization accreditation criteria requiring assessment and treatment of pain in all patients beginning January 2001, we observed a consistent and unabated increase in the rate of opioid fills and the proportion of chronic use. A parallel increase in the annual rate of adverse events was also observed. Similarly, we observed a continuous rise in the average strength of opioid fills following January 2001 with the exception of a single drop in December 2010, which was attributable to the withdrawal of propoxyphene from the U.S. market.LimitationsThis was an observational study and not a trial. Other long-term opioid-related benefits or harms, including functional status, quality of life, and substance use disorder, were not assessed.ConclusionsThis study provides temporal evidence for a rise in prescription opioid use after implementation of health organization accreditation criteria requiring standardized management of all individuals with pain.

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