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- Karen J Greer, Winslade A Bowen, and Alfred N Krauss.
- Perinatology Center, Department of Pediatrics, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA.
- Am J Perinatol. 2003 Nov 1; 20 (8): 447-51.
ObjectiveTo test the hypothesis that end-tidal CO(2) (PETCO(2)) varies with tidal volume (Vt) in preterm infants.DesignIntervention study, nonrandomized trial.SettingNeonatal ICU, regional referral center.Subjects29 preterm infants 790 to 2135 g in weight requiring mechanical ventilation studied on 73 occasions.InterventionMeasurement of PETCO(2) during variations of Vt.MeasurementStatistical correlation of PETCO(2) to Vt.ResultPETCO(2) is minimal when Vt is either too low or too high.ConclusionVt, through its effect on dead space/Vt (Vd/Vt) ratios and arterial-alveolar CO(2) differences, has a significant effect on PETCO(2). Observation of PETCO(2) across a range of Vt can be used to select an appropriate Vt for preterm infants requiring mechanical ventilation.
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