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Cancer investigation · Jun 2013
Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade: a pilot study.
- P Queirolo, A Morabito, S Laurent, S Lastraioli, P Piccioli, P A Ascierto, G Gentilcore, M Serra, A Marasco, E Tornari, B Dozin, and M P Pistillo.
- UOC Oncologia Medica A, IRCCS A.O.U. San Martino-IST, Genova, Italy.
- Cancer Invest. 2013 Jun 1; 31 (5): 336-45.
AbstractCTLA-4 blockade with monoclonal antibodies can lead to cancer regression in patients with metastatic melanoma (MM). CTLA-4 gene polymorphisms may influence the response to anti-CTLA-4 antibodies although few data are available regarding this issue. We analyzed six CTLA-4 single nucleotide polymorphisms (-1661A > G, -1577G > A, -658C > T, -319C > T, +49A > G, and CT60G > A) in 14 Italian MM patients and 45 healthy subjects. We found a significant association between the -1577G/A and CT60G/A genotypes and improved overall survival (Pc < 0.006, Bonferroni corrected), further confirmed by the diplotype analysis (-1577 & CT60 GG-AA diplotype, p < 0.001). A positive trend toward an association between these genotypes and response to therapy was also observed.
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