• Brain research · Jul 2004

    Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections.

    • Eileen Hopkins, Grace Rossi, and Benjamin Kest.
    • Neuropsychology Doctoral Subprogram, Queens College, City University of New York, Flushing, NY 11367, USA.
    • Brain Res. 2004 Jul 16; 1014 (1-2): 244-6.

    AbstractMorphine analgesic potency following systemic administration was assessed in male and female mice undergoing prior and repeated intrathecal morphine injections. Although morphine ED50 values were significantly increased in both sexes relative to their respective saline-injected controls, the magnitude of tolerance was greater in females. Intrathecal injection alone had no effect on morphine analgesia. The data suggest that spinal mechanisms contribute to sex differences in analgesic tolerance following systemic morphine administration.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…