• Eduardo A Garza-Villarreal, Zhiguo Jiang, Peter Vuust, Sarael Alcauter, Lene Vase, Erick H Pasaye, Roberto Cavazos-Rodriguez, Elvira Brattico, Troels S Jensen, and Fernando A Barrios.
• Subdireccion de Investigaciones Clinicas, Instituto Nacional de Psiquiatria "Dr. Ramón de la Fuente Muñiz," Mexico City, Mexico ; Cátedras, National Council of Science and Technology (CONACYT) Mexico City, Mexico ; Department of Neurology, Faculty of Medicine and University Hospital "Dr. Jose E. Gonzalez" and Neuroscience Unit, Center for Research and Development in the Health Sciences, Universidad Autónoma de Nuevo León Monterrey, Mexico ; Music in the Brain, Center of Functionally Integrative Neuroscience, Aarhus University Aarhus, Denmark.
• Front Psychol. 2015 Jan 1; 6: 1051.

AbstractMusic reduces pain in fibromyalgia (FM), a chronic pain disease, but the functional neural correlates of music-induced analgesia (MIA) are still largely unknown. We recruited FM patients (n = 22) who listened to their preferred relaxing music and an auditory control (pink noise) for 5 min without external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD signal was evident in the left angular gyrus (lAnG) after listening to music, which in turn, correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the lAnG showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex (rdlPFC), the left caudate (lCau), and decreased connectivity with right anterior cingulate cortex (rACC), right supplementary motor area (rSMA), precuneus and right precentral gyrus (rPreG). Pain intensity (PI) analgesia was correlated (r = 0.61) to the connectivity of the lAnG with the rPreG. Our results show that MIA in FM is related to top-down regulation of the pain modulatory network by the default mode network (DMN).

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