• Critical care clinics · Jul 2016

    Review

    Acute-on-chronic and Decompensated Chronic Liver Failure: Definitions, Epidemiology, and Prognostication.

    • Jody C Olson.
    • Hepatology and Critical Care Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 1023, Kansas City, KS 66160, USA. Electronic address: jolson2@kumc.edu.
    • Crit Care Clin. 2016 Jul 1; 32 (3): 301-9.

    AbstractChronic liver disease is the fifth leading cause of death worldwide and represents a major burden for the health care community. Cirrhosis is a progressive disease resulting in end-stage liver failure, which in the absence of liver transplantation is fatal. Acute-on-chronic liver failure carries high short-term mortality but is potentially reversible. Viral hepatitis, alcohol, and nonalcoholic fatty liver disease remain the principal causes of liver disease. Though treatments exist for hepatitis B and C, they remain unavailable to many with these diseases. This article reviews the epidemiology of advanced liver disease and the concept of acute-on-chronic liver failure. Copyright © 2016 Elsevier Inc. All rights reserved.

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