• James S Meabon, Bertrand R Huber, Donna J Cross, Todd L Richards, Satoshi Minoshima, Kathleen F Pagulayan, Ge Li, Kole D Meeker, Brian C Kraemer, Eric C Petrie, Murray A Raskind, Elaine R Peskind, and David G Cook.
• Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System (VA Puget Sound), Seattle, WA 98108, USA. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.
• Sci Transl Med. 2016 Jan 13; 8 (321): 321ra6.

AbstractBlast exposure can cause mild traumatic brain injury (TBI) in mice and other mammals. However, there are important gaps in our understanding of the neuropathology underlying repetitive blast exposure in animal models compared to the neuroimaging abnormalities observed in blast-exposed veterans. Moreover, how an increase in the number of blast exposures affects neuroimaging endpoints in blast-exposed humans is not well understood. We asked whether there is a dose-response relationship between the number of blast-related mild TBIs and uptake of (18)F-fluorodeoxyglucose (FDG), a commonly used indicator of neuronal activity, in the brains of blast-exposed veterans with mild TBI. We found that the number of blast exposures correlated with FDG uptake in the cerebellum of veterans. In mice, blast exposure produced microlesions in the blood-brain barrier (BBB) predominantly in the ventral cerebellum. Purkinje cells associated with these BBB microlesions displayed plasma membrane disruptions and aberrant expression of phosphorylated tau protein. Purkinje cell loss was most pronounced in the ventral cerebellar lobules, suggesting that early-stage breakdown of BBB integrity may be an important factor driving long-term brain changes. Blast exposure caused reactive gliosis in mouse cerebellum, particularly in the deep cerebellar nuclei. Diffusion tensor imaging tractography of the cerebellum of blast-exposed veterans revealed that mean diffusivity correlated negatively with the number of blast-related mild TBIs. Together, these results argue that the cerebellum is vulnerable to repetitive mild TBI in both mice and humans.Copyright © 2016, American Association for the Advancement of Science.

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