• Gan To Kagaku Ryoho · Oct 1993

    Clinical Trial Controlled Clinical Trial

    [Clinical effects of granisetron and methylprednisolone against nausea, vomiting and anorexia induced by cisplatin].

    • T Kawashima, T Wada, N Morita, T Ohmata, K Miyata, and T Sakamoto.
    • Dept. of Dentistry and Oral Surgery, Wakayama Medical College.
    • Gan To Kagaku Ryoho. 1993 Oct 1; 20 (13): 2043-8.

    AbstractWe investigated the usefulness of concurrent therapy of granisetron with methylprednisolone sodium for on nausea, vomiting and anorexia induced by chemotherapy, including cisplatin, in patients with oral cancer. Group A: 10 patients who were on concurrent therapy of granisetron (3.0 mg/body) with methylprednisolone sodium (750 mg/body) (19 courses). Group B: 13 patients who were given coktail therapy of methylprednisolone sodium (750 mg/body) as the base drug plus metoclopramide (46.7 mg/body on average) and domperidone (82.9 mg/body on average) (21 courses). Efficacy rates for nausea, vomiting and anorexia were 89.4%, 100% and 100% in group A, and 33.3%, 47.6% and 42.9% in group B, respectively. Statistical significance was found with nausea, vomiting and anorexia (p < 0.01). The results suggest usefulness of concurrent therapy of granisetron with methylpredonisolone sodium for cisplatin-induced nausea, vomiting and anorexia.

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