• Neuroscience letters · Nov 2007

    Spinal cord stimulation modulates activity of lumbosacral spinal neurons receiving input from urinary bladder in rats.

    • Chao Qin, Jay P Farber, and Robert D Foreman.
    • Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. chao-qin@ouhsc.edu
    • Neurosci. Lett. 2007 Nov 20; 428 (1): 38-42.

    AbstractThe aim of this study was to determine whether spinal cord stimulation (SCS) modulates activity of lumbosacral spinal neurons receiving input from the urinary bladder. Extracellular potentials of L6-S2 spinal neurons were recorded in pentobarbital anesthetized, paralyzed and ventilated male rats. SCS (50 Hz, 0.2 ms, 3-5 min, 90% motor threshold) was applied on the dorsal column of L2-L3 and C1-C2 segments and significantly reduced excitatory responses of 18/25 (72%) and 13/19 (68%) lumbosacral neurons to noxious urinary bladder distension (UBD, > or =1.0 ml, 20 s), respectively. SCS affected spinal neurons with either high- or low-threshold responses to UBD. These results suggested that SCS might have a potential therapeutic effect for patients with hypersensitivity and/or pain of cystitis and other urinary bladder disorders.

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