• Int. J. Cardiol. · Jul 2008

    Letter Randomized Controlled Trial

    Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty.

    • Sima Samimi-Fard, Martín J García-González, Alberto Domínguez-Rodríguez, and Pedro Abreu-González.
    • Int. J. Cardiol. 2008 Jul 4; 127 (2): 284-7.

    BackgroundCardiogenic shock (CS) after ST elevation myocardial infarction (STEMI) worsens patient's outcome. Levosimendan treatment offers short-term survival benefit in acute heart failure but its effect on long-term outcome remains unclear. We sought to assess the effect on long-term survival of levosimendan compared to dobutamine treatment in patients with STEMI revascularized by primary coronary angioplasty (PCI) who subsequently developed CS.Methods And ResultsTwenty-two consecutive STEMI patients with CS after PCI randomized to receive levosimendan or dobutamine treatment for 24 h were followed-up for twelve months. Complete follow-up was obtained in 100% of them. The endpoint was cardiac death. Baseline clinical and haemodynamic characteristics were similar in both groups. The probability of survival calculated with Kaplan-Meier curves analysis showed no statistically significant differences between both groups (p=0.24).ConclusionsLevosimendan compared to dobutamine did not improve long-term survival in STEMI patients revascularized by PCI who developed CS.

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