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- Jihong Han, Allison Beeton, Paul Long, Ann Karimova, Alex Robertson, Nigel Cross, Liz Smith, Maura O'Callaghan, Allan Goldman, Kate Brown, and Catherine Tuleu.
- Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK.
- Int J Pharm. 2005 Apr 27; 294 (1-2): 157-9.
AbstractA wet-primed ready-to-use extracorporeal membrane oxygenation (ECMO) circuit is used in some centres for rapid deployment of ECMO during cardiopulmonary resuscitation. Yet, the potential release of plasticizer di(2-ethylhexyl)phthalate (DEHP) from the polyvinyl chloride tubing in the circuit during storage is a concern. In this study, a high performance liquid chromatography method was used to determine the concentration of DEHP in the priming solution (Plasmalyte) from an ECMO circuit stored for up to 14 days at 8 degrees C. No accumulation of DEHP in the circulating fluid was detected. The results provide important information for centres where ECMO circuits are kept wet-primed prior to clinical use.
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