Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects. ⋯ A literature review of venlafaxine overdose cases and investigation into its mechanism of action was conducted. The potential for sodium channel blockade and implications for therapy are discussed.
George M Bosse, Henry A Spiller, and Aaron M Collins.
Department of Emergency Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
J Med Toxicol. 2008 Mar 1; 4 (1): 18-20.
IntroductionBased on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects.Case ReportA 40 year old male ingested venlafaxine without co-ingestants in a suicide attempt. The patient developed refractory ventricular fibrillation and expired approximately 9 hours post-ingestion. ECG monitoring revealed significant QRS and QTC interval prolongation prior to his demise.DiscussionA literature review of venlafaxine overdose cases and investigation into its mechanism of action was conducted. The potential for sodium channel blockade and implications for therapy are discussed.