• Expert Opin Drug Metab Toxicol · Jan 2016

    Review

    Pharmacokinetic and pharmacodynamic evaluation of sublingual sufentanil in the treatment of post-operative pain.

    • Rovnat Babazade and Alparslan Turan.
    • a Department of Outcomes Research , Cleveland Clinic , Cleveland , OH , USA.
    • Expert Opin Drug Metab Toxicol. 2016 Jan 1; 12 (2): 217-24.

    IntroductionIntravenous patient-controlled analgesia using opioids is frequently used to provide perioperative analgesia. However, there are a number of drawbacks for intravenous patient-controlled analgesia. The sufentanil sublingual tablet system is a major evolution in technology and drug development for postoperative pain management.Areas CoveredWe reviewed the use of sublingual sufentanil in postoperative pain management, with a focus on chemistry, pharmacokinetics and clinical use in different surgical patients.Expert OpinionThe sufentanil sublingual tablet system can decrease intravenous patient-controlled analgesia-related safety issues. Current clinical studies have demonstrated this novel system to be safe and effective in postoperative pain management.

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