-
- C M Little and C G Brown.
- Department of Emergency Medicine, Ohio State University, Columbus 43210.
- Resuscitation. 1993 Oct 1; 26 (2): 203-10.
AbstractEpinephrine is used to increase coronary perfusion pressure and improve myocardial blood flow during cardiac arrest. Alternative vasopressors may have hemodynamic advantages over epinephrine. The purpose of this investigation was to test the effect of the vasopressor angiotensin II on myocardial blood flow in a swine model of cardiac arrest. Eleven swine were anesthetized and instrumented for regional blood flows by radiolabeled microsphere technique. A baseline blood flow measurement (BFM), coronary sinus and aortic blood gases were obtained in normal sinus rhythm (NSR). Ventricular fibrillation (VF) was induced and mechanical CPR begun after 10 min of VF. A BFM and blood gases were obtained during CPR. Angiotensin II, 50 micrograms/kg, was administered at 13 min of VF. A repeat BFM and blood gases were obtained following angiotensin II. Defibrillation was attempted at 16.5 min of VF. If return of spontaneous circulation (ROSC) occurred a fourth BFM and blood gases were obtained. Myocardial blood flow was 134.2 +/- 40.1 ml/100 g per min during NSR. This fell to 15.1 +/- 19.9 with CPR alone, and rose to 66.9 +/- 69.8 following angiotensin II administration (P = 0.04; by two tailed T-test). Myocardial blood flow following ROSC further increased to 212.6 +/- 58.0. Angiotensin II in a dose of 50 micrograms/kg significantly increases myocardial blood flow in this model of cardiac arrest.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.