• Ugeskrift for laeger · Jun 2012

    Case Reports

    [Metformin-associated lactic acidosis can be treated with continuous renal replacement therapy].

    • Helene Korvenius Jørgensen, Jane Stab Nielsen, and Torben Gilsaa.
    • Anæstesiologisk Afdeling, Kolding Sygehus, Skovvangen 2-8, 6000 Kolding, Denmark. helene_j@yahoo.com
    • Ugeskr. Laeg. 2012 Jun 4; 174 (23): 1602-3.

    AbstractMetformin is widely used to treat diabetes. In rare cases, metformin may cause lactic acidosis, especially when administered during periods of dehydration. We present two cases of metformin-associated lactic acidosis (MALA). Both patients presented with metabolic acidosis, hypotension, renal failure and gastrointestinal symptoms. The use of continuous renal replacement therapy (CRRT) had a significant effect. Lactate and metformin can be removed effectively by haemofiltration. CRRT is widely available and a well-known treatment at intensive care units. MALA shows a mortality rate of about 30%.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…