• J Orofac Pain · Jan 2012

    Effect of estrogen and dietary loading on condylar cartilage.

    • Marko Orajärvi, Elina Puijola, Shi-Bin Yu, Xiaodong Liu, Petri Tiilikainen, Meiqing Wang, Aune Raustia, and Pertti Pirttiniemi.
    • Department of Prosthetic Dentistry and Stomatognatic Physiology.
    • J Orofac Pain. 2012 Jan 1;26(4):328-36.

    AimsTo study the effect of estrogen deficiency and altered temporomandibular joint loading on the histomorphology of condylar cartilage and on the expression of types II and X collagen and matrix metalloproteinase-3 (MMP-3).MethodsThirty-six female rats were divided into four groups: ovariectomized rats on a normal diet, nonovariectomized control rats on a normal diet, ovariectomized rats on a soft diet, and nonovariectomized control rats on a soft diet. Ovariectomy was performed at the age of 60 days. Repeated-measures ANOVA was used to analyze the data.ResultsThe condylar cartilage in the ovariectomized normal diet group showed a significantly higher number of cells than in the nonovariectomized control rats (P < .001). The proportional amount of MMP-3 expression was significantly higher in the ovariectomized rats than in the nonovariectomized control rats in both diet groups (P < .001). The area covered by types II and X collagen was significantly higher in the experimental groups than in the control groups (P < .01).ConclusionCondylar cartilage is sensitive to both estrogen level and dietary loading.

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