• G K Singh, R K Manglik, P K Lakhtakia, and A Singh.
• Department of Orthopedics, King George Medical College, Lucknow, India.
• Online J Curr Clin Trials. 1992 Oct 1; Doc No 23: [3614 words; 43 paragraphs].

ObjectiveAn alternative to general anesthesia was tested against conventional sedation by a double-blind, randomized clinical trial in reduction of Colles fracture.SettingsA large teaching hospital where cases of Colles fracture are not different from those seen in district hospitals.PatientsSixty-six out of 80 consecutive cases with this fracture were selected from March to August 1990 on the basis of: 1) informed consent; 2) no contraindication to any method of analgesia; 3) no analgesic during the past 8 hours; 4) injury duration less than 96 hours; 5) no mental, auditory, or visual impairment; and 6) no associated injury.InterventionsPatients were randomized into 2 equal groups. After tests for Xylocaine (Astra brand of lidocaine hydrochloride) sensitivity in both groups, the A group received 30 mg of pentazocine with 5 mg of diazepam intravenously on the dorsum of the affected wrist (sedation group), whereas the B group received 20 cc of 1.5% Xylocaine into the fracture hematoma. Five minutes later the fracture was reduced and immobilized by Lakhtakia or A. Singh.Main Outcome MeasuresThirteen to 15 hours later Manglik, blinded to the analgesia status of the patient, recorded pain before, during, and after reduction using Visual Analogue Scale (VAS).Main ResultsStatistically, randomization and blinding were found to be effective. The pain scores during reduction in the local anesthetic group (median = 1.8) were significantly less than those in the sedation group (median = 8.7), P < 0.001 using the Wilcoxon rank sum test. The difference persisted in regression analysis. The 2 methods proved comparable in safety and other measures of effectiveness.ConclusionsHematoma block by local anesthetic is a safe and effective alternative to sedation in reduction of Colles fracture.

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