• Junling Gao, Shi-Ting Feng, Bangxian Wu, Nanjie Gong, Minhua Lu, Po-Man Wu, He Wang, Xiaoming He, and Bingsheng Huang.
• Department of Medicine, The University of Hong Kong, Hong Kong.
• J Magn Reson Imaging. 2015 Apr 1; 41 (4): 1088-95.

PurposeTo investigate the diffusion abnormalities in the brain of children with idiopathic generalized epilepsy (IGE) with generalized tonic-clonic seizure (GTCS) by using diffusion kurtosis imaging (DKI).Materials And MethodsTwenty-one IGE children with GTCS and 16 controls were recruited. DKI was performed and maps of radial diffusivity (λ⊥ ), axial diffusivity (λ// ), mean diffusivity (MD), fractional anisotropy (FA), radial kurtosis (K⊥ ), axial kurtosis (K// ) and mean kurtosis (MK) were calculated. Voxel-based analyses were employed to compare diffusion metrics in epilepsy versus the controls.ResultsIn the case group, MD was found significantly higher in the right temporal lobe, the right occipital lobe, hippocampus, and some subcortical regions, while FA increased in bilateral supplementary motor area and the left superior frontal lobe (false discovery rate corrected P < 0.05). Analysis of λ⊥ and λ// showed that the increased MD was mainly due to the elevated λ// . Significantly decreased MK was also detected in bilateral temporo-occipital regions, the right hippocampus, the left insula, the left post-central area, and some subcortical regions (false discovery rate corrected P < 0.05). In most regions the changed MK were due to the decreased K// .ConclusionThe kurtosis parameters (K⊥ , K// , and MK) reflect different microstructural information in the IGE children with GTCS, and this support the value of DKI in studying children GTCS.© 2014 Wiley Periodicals, Inc.

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