• Clin Neurophysiol · May 2013

    Tissue oxygen saturation and pulsatility index as markers for amnestic mild cognitive impairment: NIRS and TCD study.

    • S Viola, P Viola, M P Buongarzone, L Fiorelli, and P Litterio.
    • Department of Neurology, Dementia Assessment Unit, S. Pio Hospital, via C. De Lellis, 66054 Vasto (CH), Italy. stefano.viola@email.it
    • Clin Neurophysiol. 2013 May 1; 124 (5): 851-6.

    ObjectiveTo evaluate the utility of near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) parameters as potential markers for amnestic mild cognitive impairment (aMCI).MethodsBy means of NIRS and TCD, noninvasive and inexpensive technologies, we studied 21 patients with aMCI (10 M and 11 F, 70.2 ± 7.3 years) and 10 age matched healthy controls.ResultsBy means of NIRS, we found a significant mean decrease of tissue oxygen saturation of cortex microcirculation (TOI), - 27%, p < 0.0005, on the temporal-parietal cortex of both side compared to the controls. By means of TCD, we found a significant mean increase of pulsatility index (PI), p < 0.0007, of middle cerebral artery (MCA) of both side compared to the controls. Cerebrovascular risk factors were present in 81% of the aMCI patients.ConclusionsOur study reveals that the TOI reduction on the temporal-parietal cortex of both side and the increase of PI in both MCA are associated with a clinical diagnosis of aMCI patients.SignificanceThe reduction of TOI may be considered a new marker for aMCI, especially when combined with the increase of PI in MCA.Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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