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Annals of neurology · Jun 2004
Comparative Study Clinical TrialLong-term results of bilateral pallidal stimulation in Parkinson's disease.
- Jens Volkmann, Niels Allert, Jürgen Voges, Volker Sturm, Alfons Schnitzler, and Hans-Joachim Freund.
- Department of Neurology, Heinrich-Heine-University, Düsseldorf, Cologne, Germany. j.volkmann@neurologie.uni-kiel.de
- Ann. Neurol. 2004 Jun 1; 55 (6): 871-5.
AbstractWe followed up 11 patients for up to 5 years after bilateral pallidal deep brain stimulation for advanced Parkinson's disease. Dyskinesias remained significantly reduced until the last assessment. The initial improvement of off-period motor symptoms and fluctuations, however, was not sustained and gradually declined. Beneficial effects of pallidal deep brain stimulation on activities of daily living in the on- and off-period were lost after the first year. Replacement of pallidal electrodes into the subthalamic nucleus in four patients could restore the initial benefit of deep brain stimulation and allowed a significant reduction of dopaminergic drug therapy.
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