• Mary E Cooley, David F Lobach, Ellis Johns, Barbara Halpenny, Toni-Ann Saunders, Guilherme Del Fiol, Michael S Rabin, Pamela Calarese, Isidore L Berenbaum, Ken Zaner, Kathleen Finn, Donna L Berry, and Janet L Abrahm.
• Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Electronic address: mary_cooley@dfci.harvard.edu.
• J Pain Symptom Manage. 2013 Dec 1; 46 (6): 911-924.e1.

ContextAdequate symptom management is essential to ensure quality cancer care, but symptom management is not always evidence based. Adapting and automating national guidelines for use at the point of care may enhance use by clinicians.ObjectivesThis article reports on a process of adapting research evidence for use in a clinical decision support system that provided individualized symptom management recommendations to clinicians at the point of care.MethodsUsing a modified ADAPTE process, panels of local experts adapted national guidelines and integrated research evidence to create computable algorithms with explicit recommendations for management of the most common symptoms (pain, fatigue, dyspnea, depression, and anxiety) associated with lung cancer.ResultsSmall multidisciplinary groups and a consensus panel, using a nominal group technique, modified and subsequently approved computable algorithms for fatigue, dyspnea, moderate pain, severe pain, depression, and anxiety. The approved algorithms represented the consensus of multidisciplinary clinicians on pharmacological and behavioral interventions tailored to the patient's age, comorbidities, laboratory values, current medications, and patient-reported symptom severity. Algorithms also were reconciled with one another to enable simultaneous management of several symptoms.ConclusionA modified ADAPTE process and nominal group technique enabled the development and approval of locally adapted computable algorithms for individualized symptom management in patients with lung cancer. The process was more complex and required more time and resources than initially anticipated, but it resulted in computable algorithms that represented the consensus of many experts.Copyright © 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

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