• Epilepsia · Aug 2011

    Rational approach to treatment options for Lennox-Gastaut syndrome.

    • Georgia D Montouris.
    • Department of Neurology, Boston University School of Medicine, Boston Medical Center, 72 East Concord Street, Boston, MA 02118-3294, U.S.A. georgia.montouris@bmc.org
    • Epilepsia. 2011 Aug 1; 52 Suppl 5: 10-20.

    AbstractLennox-Gastaut syndrome (LGS) is an intractable childhood-onset epileptic encephalopathy. Seizure freedom is rare in LGS. One of the hallmarks of LGS is medical intractability, with generally poor response to antiepileptic drugs (AEDs). Nevertheless, several treatment options are available that can mitigate the severity of seizures and curtail their frequency. New AEDs have been validated in randomized, controlled trials for the treatment of seizures in LGS. In some cases, nonpharmacologic options may be effective, although more data are needed to confirm efficacy outcomes. Comprehensive patient assessments are critical to achieve an optimal AED treatment regimen and minimize the potential for adverse effects.Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.

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