• Journal of medicine · Jan 1982

    Comparative Study

    Use of intrathecal and epidural morphine for pain relief in patients with malignant diseases: a preliminary report.

    • R C Rico, G H Hobika, A M Avellanosa, R J Trudnowski, J Rempel, and C R West.
    • J Med. 1982 Jan 1; 13 (3): 223-31.

    AbstractThe results of a preliminary study involving the treatment of various malignant pain disorders by intrathecal (I.T.) or epidural (E) morphine sulfate (M.S.) injections in 18 patients are reported. Fourteen (78%) patients obtained satisfactory analgesic effects and 4 (22%) failed. The overall duration of pain relief was modest and ranged from 10 to 72 hours; the intrathecal route provided a slightly longer duration (median: 48 hours; range: 15-72 hours) of analgesia than that of the epidural route (median: 20 hours; range: 10-72 hours). Minor and transient complications occurred in 10 (55%) patients.

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