• Manabu Kimoto.
• Department of Anesthesiology, Sano Kinen Hospital, Izumisano 598-0013.
• Masui. 2011 Jun 1; 60 (6): 656-60.

BackgroundIt is well known that buprenorphine compete with remifentanil for receptor binding. I have examined the effect of buprenorphine administration on postoperative analgesia following remifentanil-based anesthesia.MethodsIn this study, I enrolled 30 patients who had undergone open reduction and internal fixation for fractures at the extremities under general anesthesia. Anesthesia was maintained with continuous infusion of remifentanil, and buprenorphine was administered at the end of surgery. Postoperative pain and side effects were evaluated in all patients.ResultsSeventeen patients (57%) required additional analgesic treatment within 1 hour of initial administration of buprenorphine. Buprenorphine therapy in patients who had undergone lower limb surgery was not as effective as that in patients who had undergone upper limb surgery. Incidence of nausea and vomiting in the study population was high(37%).ConclusionsBuprenorphine is effective to some degree as a postoperative analgesic following remifentanil-based anesthesia, but is not sufficient in cases of severe postoperative pain.

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