• Curr Pain Headache Rep · Dec 2003

    Review

    Current and potential future drug therapies for tension-type headache.

    • Sait Ashina and Messoud Ashina.
    • Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, DK-2600 Glostrup, Copenhagen, Denmark. ashina@dadlnet.dk
    • Curr Pain Headache Rep. 2003 Dec 1; 7 (6): 466-74.

    AbstractTension-type headache is a common primary headache with tremendous socioeconomic impact. Establishment of an accurate diagnosis is important before initiation of any pharmacologic therapy. Simple analgesics and nonsteroidal anti-inflammatory drugs are the mainstays of treatment of episodic tension-type headache. The tricyclic antidepressant amitriptyline is the drug of choice in the preventive treatment of chronic tension-type headache. Progress in basic neuroscience has emphasized the importance of nitric oxide inhibition and N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid receptor antagonism in the treatment of chronic pain. It has been demonstrated that inhibition of nitric oxide is effective in chronic tension-type headache. These interesting data indicate that more specific and effective treatment possibilities will emerge in the future.

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