• Ph Meurin, J Y Tabet, M Monchi, H Weber, C Fabre, B Gibier, N Renaud, and A Ben Driss.
• Les Grands Prés - Centre de réadaptation Cardiaque de la Brie 27 rue Sainte Christine 77174 Villeneuve-Saint-Denis, France. philippe.meurin@hotmail.com
• Thromb. Res. 2010 Feb 1; 125 (2): 192-5.

BackgroundPoint of care (POC) devices measuring the international normalized ratio (INR) are accurate for patients with stable disease, but their efficiency has not been prospectively assessed during the "bridging period" when patients are receiving a low molecular weight heparin (LMWH) on top of a vitamin K antagonist (VKA) until the target INR is reached.Methods188 dual INR measurement using the POC (INR(POC)) and the laboratory (INR(lab)) at the same time were consecutively determined : 69 in patients receiving LMWH+VKA (bridging group) and 119 in patients receiving only a VKA (control group). INRpoc was compared to INR(lab).ResultsTest strip failure rate was higher in the bridging group than in the control group (29% vs 4%; p<0,001). In successful tests, POC accuracy was not modified by LMWH administration: the correlation coefficients between POC and lab INR values for the bridging group and the control group were 0,81 and 0,87 respectively, and the relative measure of divergence (RMD=INR(lab) - INR(poc)/INR(lab)) was lower in the bridging group than in the control group (4+/-7% vs 10+/-14%; p=0,02). Finally, clinically relevant agreement between POC and laboratory was of 90% in the bridging group and 92.1% in the control group (p=0.6).ConclusionWith the POC used (INRatio), in patients receiving LMWH when the POC gives a result, it is as accurate as in patients not receiving a LMWH.Copyright 2009 Elsevier Ltd. All rights reserved.

29 keywords...

hide…