• Niraj Mistry, Rasha Abdel-Fahim, Amal Samaraweera, Olivier Mougin, Emma Tallantyre, Christopher Tench, Tim Jaspan, Peter Morris, Paul S Morgan, and Nikos Evangelou.
• Department of Neurology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
• Mult. Scler. 2016 Sep 1; 22 (10): 1289-96.

BackgroundWhite matter lesions are frequently detected using brain magnetic resonance imaging (MRI) performed for various indications. Most are microangiopathic, but demyelination, including multiple sclerosis (MS), is an important cause; conventional MRI cannot always distinguish between these pathologies. The proportion of lesions with a central vein on 7-T T2*-weighted MRI prospectively distinguishes demyelination from microangiopathic lesions.ObjectiveTo test whether 3-T T2*-weighted MRI can differentiate MS from microangiopathic brain lesions.MethodsA total of 40 patients were studied. Initially, a test cohort of 10 patients with MS and 10 patients with microangiopathic white matter lesions underwent 3-T T2*-weighted brain MRI. Anonymised scans were analysed blind to clinical data, and simple diagnostic rules were devised. These rules were applied to a validation cohort of 20 patients (13 with MS and 7 with microangiopathic lesions) by a blinded observer.ResultsWithin the test cohort, all patients with MS had central veins visible in >45% of brain lesions, while the rest had central veins visible in <45% of lesions. By applying diagnostic rules to the validation cohort, all remaining patients were correctly categorised.Conclusion3-T T2*-weighted brain MRI distinguishes perivenous MS lesions from microangiopathic lesions. Clinical application of this technique could supplement existing diagnostic algorithms.© The Author(s), 2015.

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