• Z A Zakaria, M R Sulaiman, N A Morsid, A Aris, H Zainal, N H Mohd Pojan, and G Hanan Kumar.
• Pharmacogenomics Center, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia. shaza8174@yahoo.com
• Methods Find Exp Clin Pharmacol. 2009 Mar 1; 31 (2): 81-8.

AbstractThe present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses.Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved.

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