• Arch Iran Med · Nov 2008

    Comparative Study

    Intra-dorsal hippocampal microinjections of lithium and scopolamine induce a cross state-dependent learning in mice.

    • Batool Ghorbanalizadeh-Khalifeh-Mahaleh, Saba Taheri, Mousa Sahebgharani, Ameneh Rezayof, Ali Haeri-Rohani, and Mohammad-Reza Zarrindast.
    • Research Branch, Islamic Azad University, Tehran, Iran.
    • Arch Iran Med. 2008 Nov 1; 11 (6): 629-38.

    BackgroundLithium, a mood stabilizer, may exert adverse effects on memory. We have previously shown that lithium induces state-dependent learning. Cholinergic systems of the brain may play an important role in memory function and mood regulation. In the present study, the effects of intra-dorsal hippocampal (intra-CA1) injections of lithium and scopolamine on memory and cross state-dependent learning between the two drugs were investigated.MethodsFor memory assessment, a one-trial step-down inhibitory avoidance task was used in adult male NMRI mice.ResultsIntra-CA1 administration of lithium (0.5 and 1 microg/mouse) after training or injection of the drug (0.5microg/mouse) before testing impaired memory when retrieval was tested 24 hours later. The memory impairment by post-training lithium was reversed by pretest administration of the drug (0.5 microg/mouse, intra-CA1) suggesting lithium state-dependent learning. On the other hand, intra-CA1 administration of scopolamine (0.5, 1, and 2 microg/mouse) after training or injection of the drug (2 microg/mouse) before testing impaired memory when retrieval was tested 24 hours later. The impairment of memory by post-training injection of scopolamine (2 microg/mouse) was restored by the pretest injection of the drug (1 and 2 microg/mouse). Furthermore, memory impairment induced by post-training injection of lithium (0.5 microg/mouse) and scopolamine (2 microg/mouse) was reversed by pretest administration of scopolamine (0.5, 1, and 2 microg/mouse) and lithium (0.5 and 1 microg/mouse), respectively. The impairment by lithium was also reversed by physostigmine.ConclusionThe results suggest that microinjections of both lithium and scopolamine induce state-dependent memory and there may be a cross state-dependency between the two drugs.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…