• Clin. Exp. Hypertens. · Apr 1996

    Review

    The case for a greater blood pressure fall.

    • L Hansson.
    • Department of Geriatrics, University of Uppsala, Sweden.
    • Clin. Exp. Hypertens. 1996 Apr 1; 18 (3-4): 425-34.

    AbstractSeveral large intervention trials in hypertension have shown that treated hypertensive patients are at increased risk of cardiovascular morbidity and mortality in spite of being treated. One possible explanation for this is the fact that the treated blood pressure rarely if ever is brought down to strictly normotensive levels. Against this view is the J-curve argument that suggests that too vigorous lowering of blood pressure may increase cardiovascular risks. Two prospective intervention trials have addressed this problem, the BBB Study, which has been published, and the much larger HOT Study which is still ongoing. Some of the findings in these two trials will be discussed with an emphasis on giving an up-date of the HOT Study.

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