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Acta Neurochir. Suppl. · Jan 1997
Cerebral vascular response to hypertonic fluid resuscitation in thermal injury.
- M Barone, D F Jimenez, V H Huxley, and X F Yang.
- Division of Plastic Surgery, University of Missouri, Columbia, USA.
- Acta Neurochir. Suppl. 1997 Jan 1; 70: 265-6.
AbstractThe purpose of this project was to study the effects of various resuscitation fluid protocols in a systemically thermally injured rat sustaining 70% body surface area third degree burn using the pial window model in rats. The results show that there was a significant albumin leak in the cerebral vessels in both the experimental group which underwent no resuscitation fluid, as well as the experimental group that was resuscitated with Lactated Ringer's solution using the Parkland formula. When this was compared to the control group, as well as to the experimental group which received hypertonic hyperosmotic saline (HMS) boluses every hour, there was little if any leakage seen.
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