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- K Buerger, S J Teipel, R Zinkowski, K Blennow, H Arai, R Engel, K Hofmann-Kiefer, C McCulloch, U Ptok, R Heun, N Andreasen, J DeBernardis, D Kerkman, H- J Moeller, P Davies, and H Hampel.
- Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. katharina.buerger@psy.med.uni-muenchen.de
- Neurology. 2002 Aug 27; 59 (4): 627-9.
AbstractIn this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.
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