• J. Neurol. Sci. · Jun 2007

    A mouse model to study tau pathology related with tau phosphorylation and assembly.

    • Tobias Engel, José J Lucas, Félix Hernández, and Jesús Avila.
    • Centro de Biología Molecular "Severo Ochoa", CSIC/UAM, 28049 Madrid, Spain.
    • J. Neurol. Sci. 2007 Jun 15; 257 (1-2): 250-4.

    AbstractThe role of tau phosphorylation and tau aggregation in the pathology of a transgenic mouse model that overexpresses GSK-3beta and FTDP-17 tau has been analyzed. In that model we have suggested a possible role for tau phosphorylation, but not for tau aggregation, in the cognitive impairment found in the transgenic mouse.

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