• Rinsho Shinkeigaku · Jan 2014

    Case Reports

    [Successful treatment with bilateral deep brain stimulation of the subthalamic nucleus for benign tremulous parkinsonism].

    • Jiro Fukae, Chikashi Fukaya, Hideki Oshima, Kenji Ishii, Yoshio Tsuboi, Yoichi Katayama, and Nobutaka Hattori.
    • Departments of Neurology, Juntendo University School of Medicine.
    • Rinsho Shinkeigaku. 2014 Jan 1; 54 (6): 511-4.

    AbstractA 62-year-old man complained of resting tremor and posture tremor. In spite of presence of the tremor, other parkinsonian component was very mild. [(11)C]2β-carbomethoxy-3β-(4-fluorophenyl)-tropane ([(11)C]CFT) PET showed asymmetrical reduction of the uptake and [(11)C]raclopride PET showed slightly increased uptake in the striatum. Although he was diagnosed as having benign tremulous parkinsonism (BTP), anti-parkinsonian medications, including anti-cholinergic agent, dopamine agonist and l-dopa, were not effective for his tremor. His tremor gradually deteriorated enough to disturb writing, working, and eating. Because his quality of life (QOL) was disturbed by the troublesome tremor, deep brain stimulation of the subthalamic nucleus (STN-DBS) was performed. After STN-DBS, his tremor was dramatically improved. According to clinical course of our patient as well as previous reports, STN-DBS should be considered as a therapeutic option for BTP patients with severe tremor.

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