• Ital J Pediatr · Jan 2015

    Case Reports

    Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection.

    • Fabio Natale, Bianca Bizzarri, Veronica Cardi, Aurelia Gaeta, Paola Villani, Giuseppina Liuzzi, and Mario De Curtis.
    • Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. fab.natale@libero.it.
    • Ital J Pediatr. 2015 Jan 1; 41: 26.

    AbstractCurrently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant's cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.

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