• J Neurosurg Spine · Apr 2011

    Case Reports

    Oncogenic osteomalacia of the cervical spine: a rare case of curative resection and reconstruction.

    • Murtaza Akhter, Patrick A Sugrue, Rick Bains, and Yevgeniy A Khavkin.
    • Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 675 North St. Clair Street, Chicago, Illinois 60611, USA.
    • J Neurosurg Spine. 2011 Apr 1; 14 (4): 453-6.

    AbstractOncogenic osteomalacia (OO) is a rare paraneoplastic syndrome, with only 100 reported cases in the literature. The majority of OO-associated mesenchymal tumors are due to a lesion called phosphaturic mesenchymal tumor, mixed connective tissue (PMTMCT) variant. There have been only 6 reported cases of OO of the spine. With this paper the authors present a case of OO of the cervical spine in a patient who initially presented with multiple pathological fractures of unknown cause, and who eventually underwent staged C-5 spondylectomy followed by circumferential stabilization. Resection of the cervical lesion led to resolution of his hypophosphatemia and prevention of any further pathological fractures. The authors describe a rare cervical neoplasm, its treatment, and review the literature on this rare bony pathological entity.

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